Soft tissue sarcomas in skin: presentations and management

Semin Oncol. 2016 Jun;43(3):413-8. doi: 10.1053/j.seminoncol.2016.02.026. Epub 2016 Feb 23.

Abstract

Soft tissue sarcomas are a rare but heterogeneous family of malignant tumors that are predominantly found deep to the integumentary layer. Only a small number of these primary mesenchymal tumors actually originate from the dermal layers. A systematic approach to the evaluation and workup of these neoplasms can prevent inappropriate management. After staging evaluation, most of these tumors are primarily managed with en-bloc surgical resection. Other adjuvant therapies routinely employed include chemotherapy and radiation therapy. Proper treatment typically involves participation of a multidisciplinary care team for optimal outcome. General principles and treatment strategies will be discussed along with a review of the more common cutaneous manifestations of sarcoma.

Keywords: Cutaneous malignancy; Dermal manifestations; Sarcoma.

Publication types

  • Review

MeSH terms

  • Biopsy
  • Dermatofibrosarcoma / pathology
  • Dermatofibrosarcoma / secondary
  • Dermatofibrosarcoma / therapy
  • Hemangiosarcoma / pathology
  • Hemangiosarcoma / secondary
  • Hemangiosarcoma / therapy
  • Humans
  • Leiomyosarcoma / pathology
  • Leiomyosarcoma / secondary
  • Leiomyosarcoma / therapy
  • Sarcoma / diagnostic imaging
  • Sarcoma / pathology*
  • Sarcoma / therapy*
  • Sarcoma, Kaposi / pathology
  • Sarcoma, Kaposi / secondary
  • Sarcoma, Kaposi / therapy
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / secondary
  • Skin Neoplasms / therapy
  • Soft Tissue Neoplasms / diagnostic imaging
  • Soft Tissue Neoplasms / pathology
  • Soft Tissue Neoplasms / therapy