Leishmania DNA Replication Timing: A Stochastic Event?

Abstract

For eukaryotic genomes, DNA synthesis initiates at multiple discrete regions known as replication origins in a dynamic yet regulated manner to ensure genomic stability. Two recent studies using different approaches reveal few Leishmania origins and that origin firing may proceed in a mainly stochastic manner.

Keywords: DNA replication; Leishmania; aneuploidy; origin of replication; stochastic timing.