Total pancreatectomy and islet cell autotransplantation: Definitive treatment for chronic pancreatitis

Karla M Arce; Yu Kuei Lin; Tyler Stevens; R Matthew Walsh; Betul A Hatipoglu

doi:10.3949/ccjm.83a.15056

Total pancreatectomy and islet cell autotransplantation: Definitive treatment for chronic pancreatitis

Cleve Clin J Med. 2016 Jun:83:435-42. doi: 10.3949/ccjm.83a.15056.

Authors

Karla M Arce¹, Yu Kuei Lin¹, Tyler Stevens^{2

3}, R Matthew Walsh^{4

5}, Betul A Hatipoglu^{6

7}

Affiliations

¹ Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
² Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA.
³ Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
⁴ Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA.
⁵ Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
⁶ Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA. E-mail: hatipoglub@ccf.org.
⁷ Clinical Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.

PMID: 27281245
DOI: 10.3949/ccjm.83a.15056

Abstract

In appropriately selected patients, total pancreatectomy and islet cell autotransplant controls pain and improves quality of life while often minimizing the development of overt diabetes. Multidisciplinary management and lifelong follow-up help to maximize the benefit of this procedure. This review highlights its history, indications, metabolic outcomes, and future directions.

Publication types

Review

MeSH terms

Humans
Islets of Langerhans Transplantation / methods*
Pancreatitis, Chronic / surgery*
Transplantation, Autologous / methods
Treatment Outcome