MEK Is a Therapeutic and Chemopreventative Target in Squamous Cell Carcinoma

J Invest Dermatol. 2016 Sep;136(9):1920-1924. doi: 10.1016/j.jid.2016.05.110. Epub 2016 Jun 9.

Authors

Charles H Adelmann¹, Kimberly A Truong¹, Roger J Liang¹, Varun Bansal¹, Leah Gandee¹, Rachael C Saporito¹, Woojin Lee¹, Lili Du¹, Courtney Nicholas¹, Marco Napoli², Barbara Mino¹, Andrew P South³, Charlotte M Proby⁴, Irene M Leigh⁵, Cristian Coarfa⁶, Elsa R Flores², Kenneth Y Tsai⁷

Affiliations

¹ Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
² Department of Molecular & Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
³ Department of Dermatology, Jefferson University, Philadelphia, Pennsylvania, USA.
⁴ Centre Molecular Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland.
⁵ Jacqui Wood Cancer Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland.
⁶ Department of Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
⁷ Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address: kytsai@mdanderson.org.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use*
Apoptosis / drug effects
Azetidines / pharmacology
Azetidines / therapeutic use
Carcinoma, Squamous Cell / drug therapy*
Cell Line, Tumor
Cellular Senescence / drug effects
Humans
Mitogen-Activated Protein Kinases / antagonists & inhibitors*
Molecular Targeted Therapy / methods
Piperidines / pharmacology
Piperidines / therapeutic use
Protein Kinase Inhibitors / pharmacology
Protein Kinase Inhibitors / therapeutic use*
Pyridones / pharmacology
Pyridones / therapeutic use
Pyrimidinones / pharmacology
Pyrimidinones / therapeutic use
Skin Neoplasms / drug therapy*
Xenograft Model Antitumor Assays

Substances

Antineoplastic Agents
Azetidines
Piperidines
Protein Kinase Inhibitors
Pyridones
Pyrimidinones
trametinib
Mitogen-Activated Protein Kinases
cobimetinib

Grants and funding