Stem Cell Membrane-Coated Nanogels for Highly Efficient In Vivo Tumor Targeted Drug Delivery

Changyong Gao; Zhihua Lin; Beatriz Jurado-Sánchez; Xiankun Lin; Zhiguang Wu; Qiang He

doi:10.1002/smll.201600624

Stem Cell Membrane-Coated Nanogels for Highly Efficient In Vivo Tumor Targeted Drug Delivery

Small. 2016 Aug;12(30):4056-62. doi: 10.1002/smll.201600624. Epub 2016 Jun 23.

Authors

Changyong Gao¹, Zhihua Lin¹, Beatriz Jurado-Sánchez², Xiankun Lin¹, Zhiguang Wu¹, Qiang He¹

Affiliations

¹ Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nano Technology Research Center, Harbin Institute of Technology, Yikuangjie 2, Harbin, 150080, China.
² Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá, Alcalá de Henares, E-28871, Madrid, Spain.

PMID: 27337109
DOI: 10.1002/smll.201600624

Abstract

Stem cell membrane-coated nanogels can effectively evade clearance of the immune system, enhance the tumor targeting properties and antitumor chemotherapy efficacy of gelatin nanogels loaded doxorubicin in mice.

Keywords: biomimetic nanoparticles; stem cell membrane; targeted drug delivery; tumor therapy.

MeSH terms

Animals
Cell Membrane / chemistry*
Doxorubicin / administration & dosage
Doxorubicin / therapeutic use
Drug Carriers / chemistry*
Drug Delivery Systems / methods
Female
HeLa Cells
Humans
Mice
Nanogels
Nanoparticles / chemistry
Polyethylene Glycols / chemistry*
Polyethyleneimine / chemistry*
Stem Cells / chemistry*
Uterine Cervical Neoplasms / drug therapy

Substances

Drug Carriers
Nanogels
polyethylene glycol polyethyleneimine nanogel
Polyethylene Glycols
Doxorubicin
Polyethyleneimine