Control of memory B cell responses by extrinsic and intrinsic mechanisms

Abstract

Following primary activation, B lymphocytes generate a long-lived memory compartment to harness the organism for future reinfections by the same pathogen species. Only recently the composition and signaling signature of the scarce memory B cell pool could be explored in more detail. This review highlights current concepts of how B cells preserve their antigen experience at the cellular and molecular level.

Keywords: Affinity maturation; B cell antigen receptor; Class-switching; Germinal center; Immunoglobulin tail tyrosine; Memory B lymphocytes.