Hunger Pains: Stimulating the Appetite of the Immune System for Cancer

Judson M Englert; Jonathan D Powell

doi:10.1016/j.ccell.2016.06.019

Hunger Pains: Stimulating the Appetite of the Immune System for Cancer

Cancer Cell. 2016 Jul 11;30(1):13-15. doi: 10.1016/j.ccell.2016.06.019.

Authors

Judson M Englert¹, Jonathan D Powell²

Affiliations

¹ Department of Oncology, Sidney-Kimmel Comprehensive Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
² Department of Oncology, Sidney-Kimmel Comprehensive Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: poweljo@jhmi.edu.

PMID: 27411584
DOI: 10.1016/j.ccell.2016.06.019

Abstract

In this issue, Pietrocola et al. and Di Biase et al. independently demonstrate that caloric restriction from fasting and pharmacologic inhibition results in an enhanced immunogenic response leading to reduced tumor growth. These two studies provide an exciting connection between the emerging fields of cancer and immune metabolism.

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MeSH terms

Appetite*
Fasting
Humans
Hunger*
Immune System
Neoplasms