Hippo's Q for a big liver

Nat Cell Biol. 2016 Jul 27;18(8):835-7. doi: 10.1038/ncb3391.

Abstract

The Hippo pathway is a key regulator of organ size that has also been implicated in tumorigenesis. Yap, one of the effectors of Hippo signalling, is now reported to support these functions by promoting glutamine synthesis.

Publication types

  • News

MeSH terms

  • Animals
  • Carcinogenesis / genetics*
  • Glutamine / metabolism
  • Hippo Signaling Pathway
  • Humans
  • Liver / metabolism*
  • Organ Size / genetics
  • Organ Size / physiology
  • Protein Serine-Threonine Kinases / metabolism

Substances

  • Glutamine
  • Protein Serine-Threonine Kinases