Hemostatic system is designed to maintain blood in a fluid state yet provide important defenses against bleeding when injury occurs to the vessel. During surgery, patients are exposed to hemostatic stress causing complications of either hypercoagulability or hemorrhage. The goal of the present study was to describe the clotting changes in patients who underwent major surgeries especially procoagulant mechanisms.
Methods: 30 patients belonging to both sexes who were undergoing surgery for various reasons were included in the study. Tests to assess the integrity of hemostatic system were conducted. Results: Analysed and expressed in mean and SD. There was a significant (p < 0.05) difference in the hemostatic parameters like bleeding time, clotting time, thrombin time, platelet count and fibrinogen concentration between the preoperative and postoperative periods.