The design of peptide-amphiphiles as functional ligands for liposomal anticancer drug and gene delivery

Huihui Kuang; Sook Hee Ku; Efrosini Kokkoli

doi:10.1016/j.addr.2016.08.005

The design of peptide-amphiphiles as functional ligands for liposomal anticancer drug and gene delivery

Adv Drug Deliv Rev. 2017 Feb:110-111:80-101. doi: 10.1016/j.addr.2016.08.005. Epub 2016 Aug 16.

Authors

Huihui Kuang¹, Sook Hee Ku¹, Efrosini Kokkoli²

Affiliations

¹ Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United States.
² Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United States. Electronic address: kokkoli@umn.edu.

PMID: 27539561
DOI: 10.1016/j.addr.2016.08.005

Abstract

Liposomal nanomedicine has led to clinically useful cancer therapeutics like Doxil and DaunoXome. In addition, peptide-functionalized liposomes represent an effective drug and gene delivery vehicle with increased cancer cell specificity, enhanced tumor-penetrating ability and high tumor growth inhibition. The goal of this article is to review the recently published literature of the peptide-amphiphiles that were used to functionalize liposomes, to highlight successful designs that improved drug and gene delivery to cancer cells in vitro, and cancer tumors in vivo, and to discuss the current challenges of designing these peptide-decorated liposomes for effective cancer treatment.

Keywords: CPP; Liposomes; Nanoparticles; PEG; Stimuli-responsive; Targeted drug delivery; Targeted gene delivery.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Drug Delivery Systems / methods*
Drug Design*
Gene Transfer Techniques*
Humans
Ligands
Liposomes
Neoplasms / drug therapy*
Neoplasms / genetics*
Neoplasms / metabolism
Peptides / chemical synthesis
Peptides / chemistry*

Substances

Antineoplastic Agents
Ligands
Liposomes
Peptides