Pancreatic Cancer: A Review

Cinthya S Yabar; Jordan M Winter

doi:10.1016/j.gtc.2016.04.003

Pancreatic Cancer: A Review

Gastroenterol Clin North Am. 2016 Sep;45(3):429-45. doi: 10.1016/j.gtc.2016.04.003.

Authors

Cinthya S Yabar¹, Jordan M Winter²

Affiliations

¹ Department of Surgery, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, 1015 Walnut Street, Curtis Building, Suite 620, Philadelphia, PA 19107, USA.
² Department of Surgery, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, 1015 Walnut Street, Curtis Building, Suite 620, Philadelphia, PA 19107, USA. Electronic address: Jordan.Winter@jefferson.edu.

PMID: 27546841
DOI: 10.1016/j.gtc.2016.04.003

Abstract

Pancreatic cancer is now the third leading cause of cancer related deaths in the United States, yet advances in treatment options have been minimal over the past decade. In this review, we summarize the evaluation and treatments for this disease. We highlight molecular advances that hopefully will soon translate into improved outcomes.

Keywords: Evaluation; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Treatment.

Publication types

Review

MeSH terms

Age Factors
Antineoplastic Agents / therapeutic use
BRCA2 Protein / genetics
Carcinoma, Pancreatic Ductal / diagnosis
Carcinoma, Pancreatic Ductal / epidemiology
Carcinoma, Pancreatic Ductal / genetics*
Carcinoma, Pancreatic Ductal / therapy
Early Detection of Cancer
Endosonography
Fanconi Anemia Complementation Group C Protein / genetics
Fanconi Anemia Complementation Group G Protein / genetics
Fanconi Anemia Complementation Group N Protein
Humans
Nuclear Proteins / genetics
Pancreatectomy
Pancreatic Neoplasms / diagnosis
Pancreatic Neoplasms / epidemiology
Pancreatic Neoplasms / genetics*
Pancreatic Neoplasms / therapy
Pancreatitis, Chronic / epidemiology
Poly(ADP-ribose) Polymerase Inhibitors / therapeutic use
Positron Emission Tomography Computed Tomography
Proto-Oncogene Proteins p21(ras) / genetics
Smoking / epidemiology
Tomography, X-Ray Computed
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Proteins / genetics

Substances

Antineoplastic Agents
BRCA2 Protein
BRCA2 protein, human
FANCC protein, human
FANCG protein, human
Fanconi Anemia Complementation Group C Protein
Fanconi Anemia Complementation Group G Protein
Fanconi Anemia Complementation Group N Protein
KRAS protein, human
Nuclear Proteins
PALB2 protein, human
Poly(ADP-ribose) Polymerase Inhibitors
TP53 protein, human
Tumor Suppressor Protein p53
Tumor Suppressor Proteins
Proto-Oncogene Proteins p21(ras)