Digitally deconvolving the tumor microenvironment

Dvir Aran; Atul J Butte

doi:10.1186/s13059-016-1036-7

Digitally deconvolving the tumor microenvironment

Genome Biol. 2016 Aug 22;17(1):175. doi: 10.1186/s13059-016-1036-7.

Authors

Dvir Aran¹, Atul J Butte²

Affiliations

¹ Institute for Computational Health Sciences, University of California, Mission Hall, 550 16th Street, 4th Floor, Box 0110, San Francisco, CA, 94158-2549, USA.
² Institute for Computational Health Sciences, University of California, Mission Hall, 550 16th Street, 4th Floor, Box 0110, San Francisco, CA, 94158-2549, USA. atul.butte@ucsf.edu.

Abstract

Understanding a tumor's complex cellular heterogeneity will be crucial for the development of better treatment strategies. A new study suggests a novel method for the in silico dissociation of solid tumors and presents novel insights that have implications for immunotherapy in cancer.Please see the related Research article: www.dx.doi.org/10.1186/s13059-016-1028-7 .

Publication types

Review
Research Support, N.I.H., Extramural
Comment

MeSH terms

Combined Modality Therapy
Computer Simulation*
Genetic Therapy
Humans
Immunotherapy / methods
Models, Biological*
Molecular Targeted Therapy
Neoplasms / etiology*
Neoplasms / pathology*
Neoplasms / therapy
Tumor Microenvironment*

Grants and funding

U24 CA195858/CA/NCI NIH HHS/United States