Caspase-1 clipping causes complications for α-synuclein

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9958-60. doi: 10.1073/pnas.1610993113. Epub 2016 Aug 22.

Authors

Silke Nuber¹, Dennis J Selkoe²

Affiliations

¹ Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115; Harvard Medical School, Boston, MA 02115.
² Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115; Harvard Medical School, Boston, MA 02115 dselkoe@partners.org.

No abstract available

MeSH terms

Caspase 1 / genetics
Caspase 1 / metabolism*
Humans
Nerve Degeneration / genetics
Nerve Degeneration / pathology
Neurons / metabolism*
Neurons / pathology
Parkinson Disease / drug therapy
Parkinson Disease / genetics*
Parkinson Disease / pathology
Protein Aggregation, Pathological / genetics
Proteolysis
alpha-Synuclein / genetics
alpha-Synuclein / metabolism*

Substances

alpha-Synuclein
Caspase 1

Grants and funding

RF1 NS083845/NS/NINDS NIH HHS/United States