The epigenome: the next substrate for engineering

Minhee Park; Albert J Keung; Ahmad S Khalil

doi:10.1186/s13059-016-1046-5

The epigenome: the next substrate for engineering

Genome Biol. 2016 Aug 31;17(1):183. doi: 10.1186/s13059-016-1046-5.

Authors

Minhee Park¹, Albert J Keung², Ahmad S Khalil^{3

4}

Affiliations

¹ Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA, 02215, USA.
² Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27695, USA.
³ Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA, 02215, USA. akhalil@bu.edu.
⁴ Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA. akhalil@bu.edu.

Abstract

We are entering an era of epigenome engineering. The precision manipulation of chromatin and epigenetic modifications provides new ways to interrogate their influence on genome and cell function and to harness these changes for applications. We review the design and state of epigenome editing tools, highlighting the unique regulatory properties afforded by these systems.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Chromatin / genetics*
Epigenesis, Genetic*
Epigenomics*
Genome, Human
Humans

Substances

Chromatin

Grants and funding

F32 GM105272/GM/NIGMS NIH HHS/United States