1,10-Phenanthroline and its derivatives are novel hatching stimulants for soybean cyst nematodes

Shiori Nonaka; Tsutomu Katsuyama; Tatsuhiko Kondo; Yasuyuki Sasaki; Tadao Asami; Shunsuke Yajima; Shinsaku Ito

doi:10.1016/j.bmcl.2016.09.052

1,10-Phenanthroline and its derivatives are novel hatching stimulants for soybean cyst nematodes

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5240-5243. doi: 10.1016/j.bmcl.2016.09.052. Epub 2016 Sep 21.

Authors

Shiori Nonaka¹, Tsutomu Katsuyama¹, Tatsuhiko Kondo², Yasuyuki Sasaki¹, Tadao Asami³, Shunsuke Yajima¹, Shinsaku Ito⁴

Affiliations

¹ Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya, Tokyo 156-8502, Japan.
² Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
³ Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan; Department of Biochemistry, King Abdulaziz University, Jeddah, Saudi Arabia; JST, CREST, Japan.
⁴ Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya, Tokyo 156-8502, Japan. Electronic address: s4ito@nodai.ac.jp.

PMID: 27692853
DOI: 10.1016/j.bmcl.2016.09.052

Abstract

Soybean cyst nematode (SCN), Heterodera glycines Ichinohe, is a plant-parasitic nematode and one of the most serious soybean pests. Herein, we present the heterocyclic compound 1,10-phenanthroline (Phen) and its derivatives as novel hatching stimulants for SCN. Phen treatment promoted hatching of second-stage juveniles of SCNs in a concentration-dependent manner. In addition, the hatching of SCNs following treatment with Phen occurred more rapidly than that following treatment with the known hatching stimulant, glycinoeclepin A (GEA). Furthermore, the co-application of Phen and GEA enhanced SCN hatching rate compared with that of Phen or GEA alone. A structure-activity relationship study for Phen derivatives suggested that 2,2'-bipyridine is the essential structure of the SCN-hatching stimulants. These results suggest that Phen and its derivatives activate different hatching pathways of SCNs from GEA.

Keywords: 1,10-Phenanthroline; 2,2′-Bipyridine; Chelating agents; Glycinoeclepin; Hatching stimulants; Soybean cyst nematode.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Female
Glycine max / parasitology*
Nematoda / growth & development*
Phenanthrolines / pharmacology*
Structure-Activity Relationship

Substances

Phenanthrolines
1,10-phenanthroline