PicoGreen: a better amyloid probe than Thioflavin-T

Chem Commun (Camb). 2016 Oct 6;52(82):12163-12166. doi: 10.1039/c6cc05600h.

Abstract

PicoGreen, a cyanine based ultrafast molecular rotor, shows high affinity towards amyloid fibrils and scores a much better sensitivity than Thioflavin-T, a gold standard probe for amyloid fibrils. Detailed spectroscopic and molecular docking studies have been performed to understand the mode of interaction between PicoGreen and amyloid fibrils.

MeSH terms

  • Amyloid / chemistry*
  • Benzothiazoles
  • Fluorescent Dyes / chemistry*
  • Humans
  • Insulin / chemistry*
  • Models, Molecular
  • Molecular Docking Simulation
  • Molecular Probes / chemistry*
  • Organic Chemicals / chemistry
  • Protein Binding
  • Thiazoles / chemistry*

Substances

  • Amyloid
  • Benzothiazoles
  • Fluorescent Dyes
  • Insulin
  • Molecular Probes
  • Organic Chemicals
  • PicoGreen
  • Thiazoles
  • thioflavin T