Abstract
PicoGreen, a cyanine based ultrafast molecular rotor, shows high affinity towards amyloid fibrils and scores a much better sensitivity than Thioflavin-T, a gold standard probe for amyloid fibrils. Detailed spectroscopic and molecular docking studies have been performed to understand the mode of interaction between PicoGreen and amyloid fibrils.
MeSH terms
-
Amyloid / chemistry*
-
Benzothiazoles
-
Fluorescent Dyes / chemistry*
-
Humans
-
Insulin / chemistry*
-
Models, Molecular
-
Molecular Docking Simulation
-
Molecular Probes / chemistry*
-
Organic Chemicals / chemistry
-
Protein Binding
-
Thiazoles / chemistry*
Substances
-
Amyloid
-
Benzothiazoles
-
Fluorescent Dyes
-
Insulin
-
Molecular Probes
-
Organic Chemicals
-
PicoGreen
-
Thiazoles
-
thioflavin T