Biscylometalated iridium(iii) complexes target mitochondria or lysosomes by regulating the lipophilicity of the main ligands

Kangqiang Qiu; Yukang Liu; Huaiyi Huang; Chaofeng Liu; Hongyi Zhu; Yu Chen; Liangnian Ji; Hui Chao

doi:10.1039/c6dt03328h

Biscylometalated iridium(iii) complexes target mitochondria or lysosomes by regulating the lipophilicity of the main ligands

Dalton Trans. 2016 Oct 18;45(41):16144-16147. doi: 10.1039/c6dt03328h.

Authors

Kangqiang Qiu¹, Yukang Liu¹, Huaiyi Huang¹, Chaofeng Liu¹, Hongyi Zhu¹, Yu Chen¹, Liangnian Ji¹, Hui Chao¹

Affiliation

¹ MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.

PMID: 27722346
DOI: 10.1039/c6dt03328h

Abstract

An efficient method was developed that controls biscylometalated iridium(iii) complexes to target mitochondria or lysosomes by regulating the lipophilicity of the main ligands.

MeSH terms

Biological Transport
Cell Survival / drug effects
Coordination Complexes / chemistry
Coordination Complexes / metabolism
Coordination Complexes / pharmacology*
HeLa Cells
Humans
Iridium / chemistry*
Ligands
Lipids / chemistry*
Lysosomes / drug effects*
Lysosomes / metabolism
Mitochondria / drug effects*
Mitochondria / metabolism
Molecular Structure
Morpholines / chemistry
Morpholines / metabolism
Organophosphorus Compounds / chemistry
Organophosphorus Compounds / metabolism
Structure-Activity Relationship

Substances

Coordination Complexes
Ligands
Lipids
Morpholines
Organophosphorus Compounds
triphenylphosphine
Iridium