CCN3: stopping that achy, breaky aorta

Andrew Leask

doi:10.1007/s12079-016-0363-5

CCN3: stopping that achy, breaky aorta

J Cell Commun Signal. 2017 Mar;11(1):93-94. doi: 10.1007/s12079-016-0363-5. Epub 2016 Nov 12.

Author

Andrew Leask¹

Affiliation

¹ Departments of Dentistry and Physiology and Pharmacology, University of Western Ontario, Dental Sciences Building, London, ON, N6A 5C1, Canada. Andrew.leask@schulich.uwo.ca.

Abstract

Abdominal aortic aneurysm (AAA) affects between 2 and 8 % of males over the age of 65. Mortality if ruptured is 85 to 90 %, Recent data by Zhang and colleagues (J Clin Invest 126(4):1282-1299 2016) suggest that CCN3 might be used to treat AAA. This Bits and Bytes summarizes these findings.

Keywords: Abdominal aortic aneurysm; CCN family; CCN3; Cardiovascular disease; Matricellular proteins; Nov.

Publication types

Review