Direct dorsal hippocampal-prelimbic cortex connections strengthen fear memories

Nat Neurosci. 2017 Jan;20(1):52-61. doi: 10.1038/nn.4443. Epub 2016 Nov 21.

Abstract

The ability to regulate the consolidation and strengthening of memories for threatening experiences is critical for mental health, and its dysregulation may lead to psychopathologies. Re-exposure to the context in which the threat was experienced can either increase or decrease fear response through distinct processes known, respectively, as reconsolidation or extinction. Using a context retrieval-dependent memory-enhancement model in rats, we report that memory strengthens through activation of direct projections from dorsal hippocampus to prelimbic (PL) cortex and activation of critical PL molecular mechanisms that are not required for extinction. Furthermore, while sustained PL brain-derived neurotrophic factor (BDNF) expression is required for memory consolidation, retrieval engages PL BDNF to regulate excitatory and inhibitory synaptic proteins neuroligin 1 and neuroligin 2, which promote memory strengthening while inhibiting extinction. Thus, context retrieval-mediated fear-memory enhancement results from a concerted action of mechanisms that strengthen memory through reconsolidation while suppressing extinction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain-Derived Neurotrophic Factor / metabolism
  • Conditioning, Classical / physiology
  • Extinction, Psychological / physiology
  • Fear / physiology*
  • Hippocampus / physiology*
  • Male
  • Memory / physiology*
  • Mental Recall / physiology*
  • Models, Animal
  • Prefrontal Cortex / physiology*
  • Rats, Long-Evans

Substances

  • Brain-Derived Neurotrophic Factor