Synthesis of nanoparticle CT contrast agents: in vitro and in vivo studies

Sung June Kim; Wenlong Xu; Md Wasi Ahmad; Jong Su Baeck; Yongmin Chang; Ji Eun Bae; Kwon Seok Chae; Tae Jeong Kim; Ji Ae Park; Gang Ho Lee

doi:10.1088/1468-6996/16/5/055003

Synthesis of nanoparticle CT contrast agents: in vitro and in vivo studies

Sci Technol Adv Mater. 2015 Oct 9;16(5):055003. doi: 10.1088/1468-6996/16/5/055003. eCollection 2015 Oct.

Authors

Sung June Kim¹, Wenlong Xu¹, Md Wasi Ahmad¹, Jong Su Baeck², Yongmin Chang³, Ji Eun Bae⁴, Kwon Seok Chae⁵, Tae Jeong Kim⁶, Ji Ae Park⁷, Gang Ho Lee⁸

Affiliations

¹ Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, Korea.
² Department of Molecular Medicine and Medical & Biological Engineering, School of Medicine, KNU and Hospital, Taegu 702-701, Korea.
³ Department of Molecular Medicine and Medical & Biological Engineering, School of Medicine, KNU and Hospital, Taegu 702-701, Korea; Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, Korea.
⁴ Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, Korea.
⁵ Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, Korea; Department of Biology Education, Teacher's College, KNU, Taegu 702-701, Korea.
⁶ Institute of Biomedical Engineering Research, KNU, Taegu 702-701, Korea.
⁷ Laboratory of Nuclear Medicine Research, Molecular Imaging Research Center, Korea Institute of Radiological Medical Science, Nowon-gil 75, Seoul 139-706, Korea.
⁸ Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, Korea; Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, Korea.

Abstract

Water-soluble and biocompatible D-glucuronic acid coated Na₂WO₄ and BaCO₃ nanoparticles were synthesized for the first time to be used as x-ray computed tomography (CT) contrast agents. Their average particle diameters were 3.2 ± 0.1 and 2.8 ± 0.1 nm for D-glucuronic acid coated Na₂WO₄ and BaCO₃ nanoparticles, respectively. All the nanoparticles exhibited a strong x-ray attenuation. In vivo CT images were obtained after intravenous injection of an aqueous sample suspension of D-glucuronic acid coated Na₂WO₄ nanoparticles, and positive contrast enhancements in the kidney were clearly shown. These findings indicate that the nanoparticles reported in this study may be promising CT contrast agents.

Keywords: BaCO3; CT contrast agent; Na2WO4; nanoparticle.