Targeting SPOP with small molecules provides a novel strategy for kidney cancer therapy

Sci China Life Sci. 2017 Jan;60(1):91-93. doi: 10.1007/s11427-016-0297-2. Epub 2016 Nov 23.

Authors

Tong Zheng^{1

2}, Cai-Guang Yang³

Affiliations

¹ Laboratory of Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ Laboratory of Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. yangcg@simm.ac.cn.

PMID: 27888385
DOI: 10.1007/s11427-016-0297-2

No abstract available

MeSH terms

Carcinoma, Renal Cell / drug therapy*
Carcinoma, Renal Cell / genetics
Carcinoma, Renal Cell / metabolism
Gene Expression Regulation, Neoplastic / drug effects
Humans
Kidney Neoplasms / drug therapy*
Kidney Neoplasms / genetics
Kidney Neoplasms / metabolism
Models, Biological
Molecular Structure
Molecular Targeted Therapy
Nuclear Proteins / genetics
Nuclear Proteins / metabolism*
Repressor Proteins / genetics
Repressor Proteins / metabolism*
Signal Transduction / drug effects*
Small Molecule Libraries / chemistry
Small Molecule Libraries / therapeutic use*

Substances

Nuclear Proteins
Repressor Proteins
SPOP protein, human
Small Molecule Libraries