An Atypical Withdrawal Syndrome in Neonates Prenatally Exposed to Gabapentin and Opioids

Sean Loudin; Sara Murray; Leesa Prunty; Todd Davies; Joseph Evans; Joseph Werthammer

doi:10.1016/j.jpeds.2016.11.004

An Atypical Withdrawal Syndrome in Neonates Prenatally Exposed to Gabapentin and Opioids

J Pediatr. 2017 Feb:181:286-288. doi: 10.1016/j.jpeds.2016.11.004. Epub 2016 Nov 23.

Authors

Sean Loudin¹, Sara Murray², Leesa Prunty³, Todd Davies⁴, Joseph Evans¹, Joseph Werthammer⁵

Affiliations

¹ Department of Pediatrics, Joan C Edwards School of Medicine at Marshall University, Huntington, WV.
² Cabell Huntington Hospital, Huntington, WV.
³ Department of Pharmacy Practice, Marshall University School of Pharmacy, Huntington, WV.
⁴ Department of Clinical and Translational Science, Joan C Edwards School of Medicine of Marshall University, Huntington, WV.
⁵ Department of Pediatrics, Joan C Edwards School of Medicine at Marshall University, Huntington, WV. Electronic address: werthammer@marshall.edu.

PMID: 27889067
DOI: 10.1016/j.jpeds.2016.11.004

Abstract

We report a retrospective case series of 19 infants exposed to both opioids and gabapentin prenatally. We describe a unique behavioral phenotype in 15 of these infants and report a treatment strategy.

Keywords: NAS; co-exposure; gabapentin; neonatology; opioids; withdrawal.

MeSH terms

Amines / adverse effects*
Amines / therapeutic use
Analgesics, Opioid / adverse effects*
Analgesics, Opioid / therapeutic use
Cyclohexanecarboxylic Acids / adverse effects*
Cyclohexanecarboxylic Acids / therapeutic use
Female
Gabapentin
Humans
Infant
Infant, Newborn
Methadone / therapeutic use*
Neonatal Abstinence Syndrome / drug therapy*
Pregnancy
Prenatal Exposure Delayed Effects / epidemiology*
Retrospective Studies
gamma-Aminobutyric Acid / adverse effects*
gamma-Aminobutyric Acid / therapeutic use

Substances

Amines
Analgesics, Opioid
Cyclohexanecarboxylic Acids
gamma-Aminobutyric Acid
Gabapentin
Methadone