Design, synthesis and cytotoxicity studies of novel pyrazolo[1, 5-a]pyridine derivatives

Eur J Med Chem. 2017 Jan 27:126:277-285. doi: 10.1016/j.ejmech.2016.11.037. Epub 2016 Nov 17.

Abstract

Copper-mediated synthesis of various pyrazolo[1, 5-a]pyridine-3-carboxylates has been described. The biological activities of these molecules have been evaluated against various human cancer cell lines A549 (Lung adenocarcinoma cell line), MCF-7 (Breast carcinoma cell line), HCT-116 (Colon cancer cell line), and PC-3 (Prostate cancer cell line) through SRB assay. Compound 247 led to accumulation MCF-7 cells in G1-phase and revealed its important role in mitotic cell cycle progression.

Keywords: Cytotoxicity; Growth inhibition; MCF-7 cells; Pyrazolo[1, 5–a]pyridines; SRB assay.

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Chemistry Techniques, Synthetic
  • Dose-Response Relationship, Drug
  • Drug Design*
  • Humans
  • Pyrazoles / chemistry*
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry
  • Pyridines / pharmacology*

Substances

  • Antineoplastic Agents
  • Pyrazoles
  • Pyridines