The RAS/MAPK Axis Gets Stressed Out

Scott A Foster; Shiva Malek

doi:10.1016/j.molcel.2016.11.024

The RAS/MAPK Axis Gets Stressed Out

Mol Cell. 2016 Dec 1;64(5):854-855. doi: 10.1016/j.molcel.2016.11.024.

Authors

Scott A Foster¹, Shiva Malek²

Affiliations

¹ Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
² Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: shivam@gene.com.

PMID: 27912095
DOI: 10.1016/j.molcel.2016.11.024

Abstract

In this issue of Molecular Cell, Ritt et al. (2016) describe a stress-induced checkpoint that effectively suppresses RAS-MAPK signaling. This pathway, activated by agents such as Rigosertib that induce mitotic and oxidative stress, results in JNK-mediated inhibition of RAS-MAPK pathway components SOS and RAF.

Publication types

Comment

MeSH terms

Proto-Oncogene Proteins c-raf*
Signal Transduction / drug effects*
ras Proteins

Substances

Proto-Oncogene Proteins c-raf
ras Proteins