[Pharmacodynamics of erythromycin lactobionate during tonsillectomy in children]

Schweiz Med Wochenschr. 1989 Oct 7;119(40):1372-4.
[Article in German]

Abstract

In 22 children serum levels and concentration of erythromycin in the tonsil tissue after intravenous injection were measured. The concentration of erythromycin in the tonsils one hour after injection was four times the serum level. Two hours after injection the ratio was reduced significantly to 1.2. From the results it is concluded that perioperative antibiotic therapy with erythromycin has pharmacodynamic advantages.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Erythromycin / administration & dosage
  • Erythromycin / analogs & derivatives*
  • Erythromycin / blood
  • Erythromycin / pharmacokinetics
  • Half-Life
  • Humans
  • Infusions, Intravenous
  • Random Allocation
  • Tonsillectomy*

Substances

  • erythromycin lactobionate
  • Erythromycin