Immune Cell Intolerance for Excess Cholesterol

Scott B Widenmaier; Gökhan S Hotamışlıgil

doi:10.1016/j.immuni.2016.12.006

Immune Cell Intolerance for Excess Cholesterol

Immunity. 2016 Dec 20;45(6):1186-1188. doi: 10.1016/j.immuni.2016.12.006.

Authors

Scott B Widenmaier¹, Gökhan S Hotamışlıgil²

Affiliations

¹ Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
² Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: ghotamis@hsph.harvard.edu.

PMID: 28002726
DOI: 10.1016/j.immuni.2016.12.006

Abstract

Chronic metabolic challenges have severe consequences on physiological systems. In this issue of Immunity, Ito et al. (2016) show that defects in cholesterol metabolism in CD11c⁺ immune cells result in impaired antigen presentation and ultimately in autoimmune disease.

Publication types

Comment

MeSH terms

Antigen Presentation*
Autoimmune Diseases
Cholesterol*
Humans

Substances

Cholesterol

Grants and funding

CIHR/Canada