MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity

Neurobiol Learn Mem. 2017 Mar:139:63-68. doi: 10.1016/j.nlm.2016.12.019. Epub 2016 Dec 27.

Abstract

MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plasticity. To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the intracellular pathways that mediate experience-dependent changes in the brain.

Keywords: LTP; Mice; Morris water maze.

MeSH terms

  • Animals
  • Hippocampus / drug effects
  • Hippocampus / metabolism*
  • Male
  • Memory, Long-Term / drug effects
  • Memory, Long-Term / physiology
  • Mice
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • MicroRNAs / pharmacology
  • Neuronal Plasticity / drug effects
  • Neuronal Plasticity / genetics*
  • Spatial Learning / drug effects
  • Spatial Learning / physiology*
  • Spatial Memory / drug effects
  • Spatial Memory / physiology*

Substances

  • MicroRNAs
  • Mirn335 microRNA, mouse