Nanopolymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo

Abstract

Biocompatible and biodegradable nanopolymersomes with an unprecedented iodine content, low viscosity, and iso-osmolality achieve significantly enhanced CT imaging of blood pool and the reticuloendothelial system. Moreover, in subcutaneous and orthotopic tumor models in mice, they show enhanced in vivo imaging when compared to iohexol, a clinically used small-molecule contrast agent.

Keywords: computed tomography; contrast agents; polymersomes; targeted imaging.