Chronic Pruritus in an 18-Month-Old Male Infant Due to Anicteric Cholestasis

J Trop Pediatr. 2017 Aug 1;63(4):321-323. doi: 10.1093/tropej/fmw084.

Abstract

An 18-month-old male infant was referred to us with pruritus from 6 months of age. He was being managed as atopic eczema with emollients and antihistamines without any response to treatment. On examination, he was found to have extensive scratch marks, mild hepatomegaly and no icterus. Blood investigations were suggestive of anicteric cholestatic liver disease. Liver biopsy was suggestive of progressive familial intrahepatic cholestasis type 3. He showed symptomatic improvement after starting ursodeoxycholic acid and fat-soluble vitamins and is under follow up.

Keywords: anicteric cholestasis; chronic pruritus; infant; liver disease.

Publication types

  • Case Reports

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B / deficiency*
  • ATP Binding Cassette Transporter, Subfamily B / genetics
  • Biopsy
  • Cholestasis / complications
  • Cholestasis / diagnosis*
  • Cholestasis / genetics
  • Cholestasis, Intrahepatic / drug therapy
  • Cholestasis, Intrahepatic / genetics
  • Cholestasis, Intrahepatic / pathology*
  • Chronic Disease
  • Humans
  • Infant
  • Liver / pathology*
  • Male
  • Pruritus / etiology*
  • Treatment Outcome
  • Ursodeoxycholic Acid / therapeutic use

Substances

  • ATP Binding Cassette Transporter, Subfamily B
  • Ursodeoxycholic Acid

Supplementary concepts

  • Cholestasis, progressive familial intrahepatic 3