Biased Opioid Receptor Ligands: Gain without Pain

Ravi Ranjan; Shubhi Pandey; Arun K Shukla

doi:10.1016/j.tem.2017.01.001

Biased Opioid Receptor Ligands: Gain without Pain

Trends Endocrinol Metab. 2017 Apr;28(4):247-249. doi: 10.1016/j.tem.2017.01.001. Epub 2017 Jan 16.

Authors

Ravi Ranjan¹, Shubhi Pandey¹, Arun K Shukla²

Affiliations

¹ Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
² Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India. Electronic address: arshukla@iitk.ac.in.

PMID: 28110810
DOI: 10.1016/j.tem.2017.01.001

Abstract

Kappa opioid receptor (κ-OR) agonists are promising therapeutic candidates for pain and itch; however, they also exhibit the adverse effects of sedation and dysphoria. A recent study has demonstrated that a G protein-biased agonist for κ-OR provides effective pain and itch relief without causing sedation or dysphoria, in animal models.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Analgesics, Opioid / adverse effects
Analgesics, Opioid / therapeutic use
Animals
Humans
Models, Animal
Pain / drug therapy*
Pain / metabolism*
Pain / prevention & control
Receptors, Opioid / agonists*
Receptors, Opioid / metabolism*

Substances

Analgesics, Opioid
Receptors, Opioid