MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1

J Hematol Oncol. 2017 Jan 25;10(1):32. doi: 10.1186/s13045-017-0402-6.

Abstract

The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that miR-194 is significantly downregulated in LSCC tissues and cells, and overexpression of miR-194 inhibits the proliferation, migration, invasion, and drug resistance in LSCC cells. Moreover, Wee1 is identified as a novel direct target of miR-194. Ectopic expression of Wee1 at least in part overcomes the suppressive impacts of miR-194 on the malignant phenotypes of LSCC. Overall, our study provides new sights into the role of miR-194/Wee1 axis in LSCC and suggests a novel miR-194/Wee1-based clinical application for LSCC patients.

Keywords: Laryngeal squamous cell carcinoma; Wee1; miR-194.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biopsy
  • Carcinoma, Squamous Cell / pathology*
  • Cell Cycle Proteins / antagonists & inhibitors
  • Cell Cycle Proteins / metabolism*
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Drug Resistance, Neoplasm
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Laryngeal Neoplasms / pathology*
  • MicroRNAs / metabolism
  • MicroRNAs / physiology*
  • Neoplasm Invasiveness
  • Nuclear Proteins / antagonists & inhibitors
  • Nuclear Proteins / metabolism*
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Protein-Tyrosine Kinases / metabolism*

Substances

  • Cell Cycle Proteins
  • MIRN194 microRNA, human
  • MicroRNAs
  • Nuclear Proteins
  • Protein-Tyrosine Kinases
  • WEE1 protein, human