Design of fluorogenic probes and fluorescent-tagged inhibitors for γ-glutamyl cyclotransferase

J Pept Sci. 2017 Jul;23(7-8):618-623. doi: 10.1002/psc.2984. Epub 2017 Feb 15.

Authors

Taku Yoshiya¹, Hiromi Ii², Shugo Tsuda¹, Masayoshi Mochizuki¹, Susumu Kageyama³, Tatsuhiro Yoshiki²

Affiliations

¹ Peptide Institute, Inc., Ibaraki, Osaka, 567-0085, Japan.
² Department of Clinical Oncology, Kyoto Pharmaceutical University, Kyoto, Kyoto, 607-8412, Japan.
³ Department of Urology, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.

PMID: 28198125
DOI: 10.1002/psc.2984

No abstract available

Keywords: GGCT; activity-based probe; cancer; fluorescence; inhibitor.

MeSH terms

Animals
Drug Design*
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Fluorescence*
Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / chemistry
Fluorescent Dyes / pharmacology*
Mice
Molecular Structure
NIH 3T3 Cells
gamma-Glutamylcyclotransferase / antagonists & inhibitors*
gamma-Glutamylcyclotransferase / metabolism

Substances

Enzyme Inhibitors
Fluorescent Dyes
gamma-Glutamylcyclotransferase