Antigen-Primed CD8+ T Cells Call DCs for Back Up

Immunity. 2017 Feb 21;46(2):163-164. doi: 10.1016/j.immuni.2017.02.002.

Abstract

Encounters between naive T lymphocytes and dendritic cells (DCs) bearing adequate co-stimulatory signals are rare. In this issue of Immunity, Brewitz et al. (2017) show that chemokines secreted by CD8+ T cells recruit myeloid and plasmacytoid DCs that in turn boost CD8+ T cell activation.

Publication types

  • Comment

MeSH terms

  • Antigens
  • CD8-Positive T-Lymphocytes / cytology*
  • Chemokines
  • Dendritic Cells / cytology*
  • Lymphocyte Activation / immunology

Substances

  • Antigens
  • Chemokines