Abstract
A series of new simplified oleanolic acid saponins with a glycosyl ester moiety at C28, were efficiently prepared. Furthermore, the effect of nasal administration of the synthetic oleanolic acid saponins on the nasal anti-influenza virus antibody titer against secondary nasal inoculation of the influenza split vaccine was examined. The result revealed cinnamoyl saponin as a suitable candidate vaccine adjuvant.
Keywords:
Glycosylation; Mucosal adjuvant; Saponin; Vaccine.
Copyright © 2016. Published by Elsevier Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / chemical synthesis*
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Adjuvants, Immunologic / chemistry
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Adjuvants, Immunologic / pharmacology*
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Administration, Intranasal
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Animals
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Influenza Vaccines / administration & dosage*
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Mice
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Mice, Inbred BALB C
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Nasal Mucosa / drug effects*
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Oleanolic Acid / chemistry*
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Saponins / chemical synthesis*
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Saponins / chemistry
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Saponins / pharmacology*
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Spectrum Analysis / methods
Substances
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Adjuvants, Immunologic
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Influenza Vaccines
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Saponins
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Oleanolic Acid