17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester from Streptomyces sp. SR107

Chin J Nat Med. 2016 Dec;14(12):931-933. doi: 10.1016/S1875-5364(17)30018-3.

Abstract

A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester (1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on the basis of its spectral data (1H NMR, 13C NMR, 1H-1H COSY, HSQC, HMBC, NOESY, IR and HR-ESI-MS). The antibacterial activity was also evaluated in this paper.

Keywords: 17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester; Antibacterial activity; Diterpenes; Streptomyces sp. SR107.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects
  • Diterpenes / chemistry*
  • Diterpenes / metabolism
  • Diterpenes / pharmacology*
  • Esters / chemistry
  • Esters / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Streptomyces / chemistry*

Substances

  • 16,17-dihydroxycyclooctatin
  • Anti-Bacterial Agents
  • Diterpenes
  • Esters