Abstract
The binding of the delta selective agonist [3H]DPDPE to diencephalic rat brain tissue was examined. Although most material examined gave rise to a single receptor model, one commercial preparation (Amersham, batch 8) suggested a two receptor model. Purification by HPLC removed a minor component and restored a single receptor model to the major component.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain / metabolism*
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Enkephalin, D-Penicillamine (2,5)-
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Enkephalins / isolation & purification
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Enkephalins / metabolism*
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Enkephalins / standards
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Quality Control
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Rats
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Receptors, Opioid / metabolism*
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Receptors, Opioid, delta
Substances
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Enkephalins
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Receptors, Opioid
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Receptors, Opioid, delta
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Enkephalin, D-Penicillamine (2,5)-