Case-control study on occupational exposure to extremely low-frequency electromagnetic fields and glioma risk

Am J Ind Med. 2017 May;60(5):494-503. doi: 10.1002/ajim.22707. Epub 2017 Apr 10.

Abstract

Background: Exposure to extremely low-frequency electromagnetic fields (ELF-EMF) was in 2002 classified as a possible human carcinogen, Group 2B, by the International Agency for Research on Cancer at WHO.

Methods: Life time occupations were assessed in case-control studies during 1997-2003 and 2007-2009. An ELF-EMF Job-Exposure Matrix was used for associating occupations with ELF exposure (μT). Cumulative exposure (μT-years), average exposure (μT), and maximum exposed job (μT) were calculated.

Results: Cumulative exposure gave for astrocytoma grade IV (glioblastoma multiforme) in the time window 1-14 years odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.4-2.6, p linear trend <0.001, and in the time window 15+ years OR = 0.9, 95%CI = 0.6-1.3, p linear trend = 0.44 in the highest exposure categories 2.75+ and 6.59+ μT years, respectively.

Conclusion: An increased risk in late stage (promotion/progression) of astrocytoma grade IV for occupational ELF-EMF exposure was found.

Keywords: ELF-EMF; RF-EMF; astrocytoma; electromagnetic fields; glioma; occupational exposure; risk factors; wireless phones.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brain Neoplasms / epidemiology*
  • Brain Neoplasms / etiology*
  • Case-Control Studies
  • Electromagnetic Fields / adverse effects*
  • Female
  • Glioblastoma / epidemiology
  • Glioblastoma / etiology
  • Glioma / epidemiology*
  • Glioma / etiology*
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Occupational Exposure / adverse effects*
  • Occupational Exposure / analysis
  • Registries
  • Risk Factors
  • Surveys and Questionnaires
  • Sweden / epidemiology
  • Young Adult