Efficient and practical synthesis of Fondaparinux

Abstract

Combining advantageous sequences of Alchemia and Sanofi methods of synthesis of Fondaparinux, a more efficient and practical synthetic strategy for the synthesis of corresponding protected pentasaccharide was developed. The protected pentasaccharide was smoothly converted into Fondaparinux in overall high yield (1%).

Keywords: Fondaparinux; Glycosylation; Sulfation; Synthesis.