Abstract
Two new kaurane-type diterpenoids, 3α-(angeloyloxy)-17-hydroxy-ent-kaur-15-en-19-oic acid (1) and 3α-(tigloyloxy)-17-hydroxy-ent-kaur-15-en-19-oic acid (2), along with 10 known compounds (3-12) were isolated from the whole plant of Wedelia chinensis (Osbeck.) Merr. Their structures were elucidated on the basis of extensive spectroscopic analyses (UV, IR, MS and NMR) and comparison with literature data. Compounds 3 and 4 showed moderate inhibitory activity against the Staphylococcus aureus subsp. aureus ATCC29213 with MIC50 19.35 and 18.31 μg/mL, respectively.
Keywords:
Wedelia chinensis; antibacterial activity; kaurane-type diterpenoids.
MeSH terms
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / pharmacology*
-
Diterpenes
-
Diterpenes, Kaurane / chemistry*
-
Diterpenes, Kaurane / pharmacology*
-
Drug Evaluation, Preclinical / methods
-
Escherichia coli / drug effects
-
Magnetic Resonance Spectroscopy
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Pseudomonas aeruginosa / drug effects
-
Salmonella enterica / drug effects
-
Spectrophotometry, Ultraviolet
-
Staphylococcus aureus / drug effects
-
Wedelia / chemistry*
Substances
-
3alpha-(angeloyloxy)-17-hydroxy-ent-kaur-15-en-19-oic acid
-
3alpha-(tigloyloxy)-17-hydroxy-ent-kaur-15-en-19-oic acid
-
Anti-Bacterial Agents
-
Diterpenes
-
Diterpenes, Kaurane
-
17-hydroxy-ent-kaur-15-en-19-oic acid