Treg Cells Survive and Thrive in Inhospitable Environments

Katarzyna M Grzes; Cameron S Field; Edward J Pearce

doi:10.1016/j.cmet.2017.05.012

Treg Cells Survive and Thrive in Inhospitable Environments

Cell Metab. 2017 Jun 6;25(6):1213-1215. doi: 10.1016/j.cmet.2017.05.012.

Authors

Katarzyna M Grzes¹, Cameron S Field¹, Edward J Pearce²

Affiliations

¹ Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
² Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany. Electronic address: pearceed@ie-freiburg.mpg.de.

PMID: 28591629
DOI: 10.1016/j.cmet.2017.05.012

Abstract

Immune responses are dangerous by nature and require regulation to prevent inflammatory and/or autoimmune sequelae and allow healing. CD4⁺Foxp3⁺ T cells (Treg cells) play a crucial role in this process, and in this edition of Cell Metabolism, Angelin et al. (2017) describe how these cells are metabolically adapted to the job.

Publication types

Comment

MeSH terms

CD4-Positive T-Lymphocytes
Forkhead Transcription Factors*
Glucose
Lactic Acid
T-Lymphocytes, Regulatory*

Substances

Forkhead Transcription Factors
Lactic Acid
Glucose