Polyprenylated acylphloroglucinols from Hypericum scabrum

Rangdong Liu; Yalun Su; Jianbo Yang; Aiguo Wang

doi:10.1016/j.phytochem.2017.06.011

Polyprenylated acylphloroglucinols from Hypericum scabrum

Phytochemistry. 2017 Oct:142:38-50. doi: 10.1016/j.phytochem.2017.06.011. Epub 2017 Jul 1.

Authors

Rangdong Liu¹, Yalun Su¹, Jianbo Yang², Aiguo Wang³

Affiliations

¹ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
² State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: yjb@imm.ac.cn.
³ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: wangaiguo@imm.ac.cn.

PMID: 28675829
DOI: 10.1016/j.phytochem.2017.06.011

Abstract

Fourteen phloroglucinols, named hyperciumoxide A-N, and a known compound were isolated from air-dried aerial parts of Hypericum scabrum. The structures of these compounds were deduced on the basis of extensive 1D- and 2D-NMR experiments. Hepatoprotective properties against D-galactosamine-induced HL-7702 cell damage of isolated compounds were evaluated. Meanwhile, these compounds were also tested for antidepressant activity by inhibiting reuptake of tritiated serotonin ([³H]-5-HT) and Noradrenalinet ([³H]-NE) in rat brain synaptosomes.

Keywords: Antidepressive; Biosynthesis; Hepatoprotective; Hypericaceae; Hypericum scabrum; PPAPs.

MeSH terms

Animals
Antidepressive Agents / chemistry
Antidepressive Agents / isolation & purification*
Antidepressive Agents / pharmacology
Brain / drug effects
Cyclohexanones / chemistry
Cyclohexanones / isolation & purification
Cyclohexanones / pharmacology
Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / isolation & purification*
Drugs, Chinese Herbal / pharmacology
HL-60 Cells
Heterocyclic Compounds, Bridged-Ring / chemistry
Heterocyclic Compounds, Bridged-Ring / pharmacology*
Humans
Hypericum / chemistry*
Liver / drug effects
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Phloroglucinol / analogs & derivatives
Phloroglucinol / chemistry
Phloroglucinol / isolation & purification*
Phloroglucinol / pharmacology
Plant Components, Aerial / chemistry*
Rats
Serotonin Antagonists / chemistry
Serotonin Antagonists / isolation & purification*
Serotonin Antagonists / pharmacology

Substances

Antidepressive Agents
Cyclohexanones
Drugs, Chinese Herbal
Heterocyclic Compounds, Bridged-Ring
Serotonin Antagonists
hyperciumoxide N
cyclohexanone
Phloroglucinol