Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions

Alexandra Epp; Juliane Hobusch; Yannic C Bartsch; Janina Petry; Gina-Maria Lilienthal; Carolien A M Koeleman; Simon Eschweiler; Christian Möbs; Ashley Hall; Suzanne C Morris; Dominique Braumann; Christine Engellenner; Josephine Bitterling; Johann Rahmöller; Alexei Leliavski; Robina Thurmann; Mattias Collin; Kelley W Moremen; Richard T Strait; Véronique Blanchard; Arnd Petersen; Timo Gemoll; Jens K Habermann; Frank Petersen; Andreas Nandy; Helga Kahlert; Michael Hertl; Manfred Wuhrer; Wolfgang Pfützner; Uta Jappe; Fred D Finkelman; Marc Ehlers

doi:10.1016/j.jaci.2017.06.021

Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions

J Allergy Clin Immunol. 2018 Jan;141(1):399-402.e8. doi: 10.1016/j.jaci.2017.06.021. Epub 2017 Jul 18.

Authors

Alexandra Epp¹, Juliane Hobusch¹, Yannic C Bartsch¹, Janina Petry¹, Gina-Maria Lilienthal¹, Carolien A M Koeleman², Simon Eschweiler¹, Christian Möbs³, Ashley Hall⁴, Suzanne C Morris⁵, Dominique Braumann⁶, Christine Engellenner⁷, Josephine Bitterling¹, Johann Rahmöller⁸, Alexei Leliavski¹, Robina Thurmann¹, Mattias Collin⁹, Kelley W Moremen¹⁰, Richard T Strait⁴, Véronique Blanchard¹¹, Arnd Petersen¹², Timo Gemoll¹³, Jens K Habermann¹³, Frank Petersen⁷, Andreas Nandy¹⁴, Helga Kahlert¹⁴, Michael Hertl³, Manfred Wuhrer², Wolfgang Pfützner³, Uta Jappe¹⁵, Fred D Finkelman¹⁶, Marc Ehlers¹⁷

Affiliations

¹ Laboratories of Immunology and Antibody Glycan Analysis, Institute for Nutrition Medicine, University of Lübeck & University Medical Center Schleswig Holstein, Lübeck, Germany.
² Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
³ Department of Dermatology and Allergology, Philipps University Marburg, Marburg, Germany.
⁴ Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
⁵ Division of Immunology, Allergy and Rheumatology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
⁶ Laboratories of Immunology and Antibody Glycan Analysis, Institute for Nutrition Medicine, University of Lübeck & University Medical Center Schleswig Holstein, Lübeck, Germany; Laboratory of Glycodesign and Glycoanalytics, Institute for Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité-University Medicine Berlin, Berlin, Germany.
⁷ Division of Biochemical Immunology, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany.
⁸ Laboratories of Immunology and Antibody Glycan Analysis, Institute for Nutrition Medicine, University of Lübeck & University Medical Center Schleswig Holstein, Lübeck, Germany; Department of Anesthesiology and Intensive Care, University Medical Center Schleswig Holstein, Lübeck, Germany.
⁹ Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden.
¹⁰ Complex Carbohydrate Research Center, University of Georgia, Athens, Ga.
¹¹ Laboratory of Glycodesign and Glycoanalytics, Institute for Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité-University Medicine Berlin, Berlin, Germany.
¹² Division of Clinical & Molecular Allergology, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, Germany.
¹³ Section for Translational Surgical Oncology & Biobanking, Department of Surgery, University of Lübeck & Univesity Medical Center Schleswig Holstein, Lübeck, Germany.
¹⁴ Research and Preclinical Development, Allergopharma GmbH & Co. KG, a business of Merck, Darmstadt, Germany.
¹⁵ Division of Clinical & Molecular Allergology, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, Germany; Interdisciplinary Allergy Outpatient Clinic, Department of Internal Medicine, University of Lübeck, Lübeck, Germany.
¹⁶ Division of Immunology, Allergy and Rheumatology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio.
¹⁷ Laboratories of Immunology and Antibody Glycan Analysis, Institute for Nutrition Medicine, University of Lübeck & University Medical Center Schleswig Holstein, Lübeck, Germany. Electronic address: marc.ehlers@uk-sh.de.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Glycosylation
Humans
Hypersensitivity / immunology*
Hypersensitivity / metabolism*
Immunoglobulin G / immunology*
Immunoglobulin G / metabolism*
Immunomodulation*
Protein Processing, Post-Translational

Substances

Immunoglobulin G

Publication types

MeSH terms

Substances

Grants and funding