Sweet Sixteenth for ChREBP: Established Roles and Future Goals

Aya Abdul-Wahed; Sandra Guilmeau; Catherine Postic

doi:10.1016/j.cmet.2017.07.004

Sweet Sixteenth for ChREBP: Established Roles and Future Goals

Cell Metab. 2017 Aug 1;26(2):324-341. doi: 10.1016/j.cmet.2017.07.004.

Authors

Aya Abdul-Wahed¹, Sandra Guilmeau¹, Catherine Postic²

Affiliations

¹ Inserm, U1016, Institut Cochin, 75014 Paris, France; CNRS UMR 8104, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.
² Inserm, U1016, Institut Cochin, 75014 Paris, France; CNRS UMR 8104, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France. Electronic address: catherine.postic@inserm.fr.

PMID: 28768172
DOI: 10.1016/j.cmet.2017.07.004

Abstract

With the identification of ChREBP in 2001, our interest in understanding the molecular control of carbohydrate sensing has surged. While ChREBP was initially studied as a master regulator of lipogenesis in liver and fat tissue, it is now clear that ChREBP functions as a central metabolic coordinator in a variety of cell types in response to environmental and hormonal signals, with wide implications in health and disease. Celebrating its sweet sixteenth birthday, we review here the current knowledge about the function and regulation of ChREBP throughout usual and less explored tissues, to recapitulate ChREBP's role as a whole-body glucose sensor.

Keywords: ChREBP; MondoB; NAFLD; cancer; de novo lipogenesis; energy homeostasis; glucose sensing; glucotoxicity; metabolic disorders; steatosis.

Publication types

Review

MeSH terms

Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism*
Glucose / metabolism*
Humans
Lipogenesis / physiology*
Liver / metabolism*

Substances

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
MLXIPL protein, human
Glucose