A Little Bit of Guidance: Mini Brains on Their Route to Adolescence

Philipp Koch; Julia Ladewig

doi:10.1016/j.stem.2017.07.001

A Little Bit of Guidance: Mini Brains on Their Route to Adolescence

Cell Stem Cell. 2017 Aug 3;21(2):157-158. doi: 10.1016/j.stem.2017.07.001.

Authors

Philipp Koch¹, Julia Ladewig²

Affiliations

¹ Institute of Reconstructive Neurobiology, University of Bonn, Bonn, 53127, Germany.
² Institute of Reconstructive Neurobiology, University of Bonn, Bonn, 53127, Germany. Electronic address: jladewig@uni-bonn.de.

PMID: 28777940
DOI: 10.1016/j.stem.2017.07.001

Abstract

Cerebral organoids represent a new model in which to study human brain development outside the human body. Recently in Nature Biotechnology, Lancaster et al. (2017) tackled the lack of reproducibility, tissue homogeneity, and complexity of this system by bioengineering organoids to establish the next generation of human mini brains.

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MeSH terms

Adolescent
Brain*
Cerebral Cortex
Humans
Organogenesis
Organoids*
Reproducibility of Results