Abstract
The plasmid-mediated colistin resistance gene, mcr-1, was identified for the first time from a hospitalized patient in South Korea. The mcr-1 gene was successfully transferred to E. coli J53 recipient and conferred resistance to colistin in the recipient. The mcr-1-harboring plasmid possessed a typical IncI2 group and did not have the mcr-1-associated ISApl1 element.
Keywords:
Colistin-resistant; E. coli; mcr-1.
Copyright © 2017 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Base Sequence
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Colistin / pharmacology*
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Drug Resistance, Multiple, Bacterial / genetics*
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Escherichia coli / drug effects*
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Escherichia coli / genetics*
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Escherichia coli / isolation & purification
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Escherichia coli Infections / drug therapy
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Escherichia coli Infections / microbiology
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Escherichia coli Proteins / genetics*
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Genome, Bacterial / genetics
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Humans
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Livestock / microbiology
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Microbial Sensitivity Tests
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Plasmids / genetics
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Republic of Korea
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Sequence Analysis, DNA
Substances
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Anti-Bacterial Agents
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Escherichia coli Proteins
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MCR-1 protein, E coli
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Colistin