Prenatal Risk Factors for PHACE Syndrome: A Study Using the PHACE Syndrome International Clinical Registry and Genetic Repository

Joy Wan; Jack Steiner; Eulalia Baselga; Francine Blei; Maria Cordisco; Maria C Garzon; Deborah S Goddard; Anita Haggstrom; Alfons Krol; Ilona J Frieden; Denise Metry; Kimberly D Morel; Judith M A Verhagen; Orli Wargon; Beth A Drolet; Dawn H Siegel

doi:10.1016/j.jpeds.2017.06.055

Prenatal Risk Factors for PHACE Syndrome: A Study Using the PHACE Syndrome International Clinical Registry and Genetic Repository

J Pediatr. 2017 Nov:190:275-279. doi: 10.1016/j.jpeds.2017.06.055. Epub 2017 Sep 1.

Authors

Joy Wan¹, Jack Steiner², Eulalia Baselga³, Francine Blei⁴, Maria Cordisco⁵, Maria C Garzon⁶, Deborah S Goddard⁷, Anita Haggstrom⁸, Alfons Krol⁹, Ilona J Frieden¹⁰, Denise Metry¹¹, Kimberly D Morel⁶, Judith M A Verhagen¹², Orli Wargon¹³, Beth A Drolet¹⁴, Dawn H Siegel¹⁴

Affiliations

¹ Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA. Electronic address: Joy.Wan@uphs.upenn.edu.
² Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI.
³ Pediatric Dermatology Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
⁴ Vascular Anomalies Program, Lenox Hill Hospital, Northwell Health, New York, NY.
⁵ Department of Dermatology, University of Rochester Medical Center, Rochester, NY.
⁶ Department of Dermatology, Columbia University, New York, NY; Department of Pediatrics, Columbia University, New York, NY.
⁷ Kuchnir Dermatology & Dermatologic Surgery, Framingham and Milford, MA.
⁸ Department of Dermatology, School of Medicine, Indiana University, Indianapolis, IN.
⁹ Department of Dermatology, Oregon Health & Science University, Portland, OR; Department of Pediatrics, Oregon Health & Science University, Portland, OR.
¹⁰ Department of Dermatology, University of California San Francisco, San Francisco, CA.
¹¹ Department of Dermatology, Texas Children's/Baylor College of Medicine, Houston, TX.
¹² Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
¹³ Department of Pediatric Dermatology, Sydney Children's Hospital School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
¹⁴ Departments of Dermatology and Pediatrics, Section of Pediatric Dermatology, Medical College of Wisconsin, Milwaukee, WI.

Abstract

The cause of PHACE syndrome is unknown. In a study of 218 patients, we examined potential prenatal risk factors for PHACE syndrome. Rates of pre-eclampsia and placenta previa in affected individuals were significantly greater than in the general population. No significant risk factor differences were detected between male and female subjects.

Keywords: disease pathogenesis; hemangioma; perinatal risk factors.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Aortic Coarctation / epidemiology
Aortic Coarctation / etiology*
Cross-Sectional Studies
Eye Abnormalities / epidemiology
Eye Abnormalities / etiology*
Female
Humans
Infant, Newborn
Male
Neurocutaneous Syndromes / epidemiology
Neurocutaneous Syndromes / etiology*
Placenta Previa
Pre-Eclampsia
Pregnancy
Prenatal Care / statistics & numerical data
Registries
Risk Factors
United States / epidemiology

Supplementary concepts

PHACE association

Abstract

Publication types

MeSH terms

Supplementary concepts

Grants and funding