A Molecular Code for Imprinting Drug-Cue Associations

Adrian M Gomez; Michael R Bruchas

doi:10.1016/j.neuron.2017.09.018

A Molecular Code for Imprinting Drug-Cue Associations

Neuron. 2017 Sep 27;96(1):3-5. doi: 10.1016/j.neuron.2017.09.018.

Authors

Adrian M Gomez¹, Michael R Bruchas²

Affiliations

¹ Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
² Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: bruchasm@wustl.edu.

PMID: 28957674
DOI: 10.1016/j.neuron.2017.09.018

Abstract

Previous studies suggest that nuclear histone deacetylase HDAC5 has a dynamic relationship with drug-induced behavioral neuroadaptations. The new work by Taniguchi et al. (2017) suggests that targets of nuclear HDAC5 mediate the behavioral effects of rewarding drugs via regulation of cocaine-associated stimuli.

Keywords: HDAC5; Npas4; cocaine; nucleus accumbens.

MeSH terms

Cocaine*
Cues*
Histone Deacetylases
Humans
Reward

Substances

Histone Deacetylases
Cocaine