Adjunctive alprazolam for schizophrenia with panic anxiety: clinical observation and pathogenetic implications

Am J Psychiatry. 1988 Jun;145(6):742-4. doi: 10.1176/ajp.145.6.742.

Abstract

Seven patients with schizophrenia and panic attacks all showed marked improvement of positive and negative schizophrenic symptoms when alprazolam was openly added to antipsychotic medication. Panic attacks may identify alprazolam-responsive schizophrenic patients and may define a distinct pathophysiologic subgroup.

MeSH terms

  • Adolescent
  • Adult
  • Alprazolam / therapeutic use*
  • Antipsychotic Agents / therapeutic use*
  • Anxiety Disorders / complications
  • Anxiety Disorders / drug therapy*
  • Anxiety Disorders / psychology
  • Dopamine / physiology
  • Drug Therapy, Combination
  • Fear*
  • Female
  • Humans
  • Male
  • Panic*
  • Pilot Projects
  • Schizophrenia / complications
  • Schizophrenia / drug therapy*
  • Schizophrenia / physiopathology
  • Schizophrenic Psychology

Substances

  • Antipsychotic Agents
  • Dopamine
  • Alprazolam