Introduction: Alzheimer disease (AD) is a neurodegenerative disease characterised by progressive dementia associated with global cognitive dysfunction.
Methods: We conducted a systematic review and meta-analysis of clinical trials evaluating omega-3 supplementation in patients with AD.
Objective: To determine if there is scientific evidence of the effectiveness of omega-3 supplementation in improving cognitive function in patients with AD.
Search strategy: We included only randomised controlled trials (RCTs) from the following databases: Medline, Cochrane Central, Cinahl, and LILACS. An electronic search was also conducted using Google Scholar.
Study selection: Six articles met the eligibility criteria. The risk of bias was assessed following the Cochrane method.
Conclusion: There is no consistent evidence to support the effectiveness of omega-3 supplementation in improving cognitive function in AD patients in the short and medium term.
Keywords: Alzheimer disease; Cognitive function; Enfermedad de Alzheimer; Ensayo clínico aleatorizado; Función cognitiva; Omega-3 fatty acids; Randomised controlled trial; Revisión sistemática; Systematic review; Ácidos grasos omega-3.
Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.