Abstract
Houttuynoid M (1), a new houttuynoid, and the related known compound houttuynoid A (2) were isolated from Houttuynia cordata. Their structures were defined using NMR data analysis, HR-MSn experiment, and chemical derivatization. Houttuynoid M is the first example of a houttuynoid with a bis-houttuynin chain tethered to a flavonoid core. A putative biosynthetic pathway of houttuynoid M (1) is proposed. The anti-herpes simplex virus (anti-HSV) activities of 1 and 2 (IC50 values of 17.72 and 12.42 μM, respectively) were evaluated using a plaque formation assay with acyclovir as the positive control.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclovir / pharmacology
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Aldehydes / chemistry
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology*
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Herpesvirus 1, Human / drug effects*
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Houttuynia / chemistry*
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Molecular Structure
Substances
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Aldehydes
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Antiviral Agents
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Drugs, Chinese Herbal
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Flavonoids
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Glycosides
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houttuynoid M
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decanoyl acetaldehyde
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Acyclovir